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pentobarbital will minimize the level or effect of lumefantrine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration with solid CYP3A4 inducers may end up in lowered serum concentrations and loss of antimalarial efficacypentobarbital will lessen the extent or impact of nelfinavir by impacting hepatic/intestina